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Home / Primary Antibodies / Polyclonal Antibodies

WIPI1 antibody

SKU : BHA10809486

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Mfr.No.	FNab09512
Alternative Names	ATG18 ; Atg18proteinhomolog ; FLJ10055 ; WIPI1 ; WIPI49kDa ; WIPI1 ; WIPI49
Background	This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alteative splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation- induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway.
Host	Rabbit
Immunogen	WD repeat domain, phosphoinositide interacting 1
Isotype	IgG
Molecular Weight	46 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ATG18, Atg18 protein homolog, FLJ10055, WIPI 1, WIPI 49 kDa, WIPI1, WIPI49

Uniprot	Q5MNZ9
Gene Id	55062
Research Area	Metabolism
Weight	49kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab09512.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809486	FNab09512	100ug	$280		Add to Cart

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