Involved in the endosomal multivesicular bodies(MVB) pathway. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR(By similarity). Involved in HIV-1 budding.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Endosome, Membrane
Clonality
polyclonal
Description
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.
Host
Rabbit
Immunogen
Vps20-associated 1 homolog
Isotype
IgG
Molecular Weight
45 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cytoplasm, Endosome, Membrane
Synonyms
C6orf55, DRG 1, DRG1, FLJ27228, HSPC228, LIP5, LYST interacting protein 5, My012, SBP1, SKD1 binding protein 1, VTA1
Antigen
VTA1
Uniprot
Q9NP79
Gene Id
51534
Research Area
Signal Transduction
Weight
34kDa,observed 45kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)