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Home / Primary Antibodies / Polyclonal Antibodies

VPS11 antibody

SKU : BHA10809401

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Mfr.No.	FNab09426
Alternative Names	END1 ; hVPS11 ; PEP5 ; RINGfingerprotein108 ; RNF108 ; VPS11
Background	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations(PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes(PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes(PubMed:21148287). Involved in the retrograde Shiga toxin transport(PubMed:23593995).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).
Host	Rabbit
Immunogen	vacuolar protein sorting 11 homolog
Isotype	IgG
Molecular Weight	108 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	END1, hVPS11, PEP5, RING finger protein 108, RNF108, VPS11

Antigen	VPS11
Uniprot	Q9H270
Gene Id	55823
Research Area	Signal Transduction
Weight	108kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IF, FC, IP

Description

ELISA ; WB ; IF ; FC ; IP

Dilution

WB	1:500-1:5000
IF	1:10-1:100
IP	1:200-1:2000

Tested Application

WB: 1:500-1:5000; IF: 1:10-1:100; IP: 1:200-1:2000; FC:N/A

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809401	FNab09426	100ug	$260		Add to Cart

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