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Home / Primary Antibodies / Polyclonal Antibodies

TRAF2 antibody

SKU : BHA10810102

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Mfr.No.	FNab10115
Background	The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Clonality	polyclonal
Host	Rabbit
Immunogen	TNF receptor-associated factor 2
Immunogen Region	TNF receptor-associated factor 2
Isotype	IgG
Molecular Weight	54 kDa
Reactivity	Human, Mouse, Rat
Recommended Dilution	WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Synonyms	TRAF2, TRAP, TRAP3

Uniprot	Q12933
Gene Id	7186
Research Area	Epigenetics, Signal Transduction, Metabolism

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10115.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810102	FNab10115	100ug	$260		Add to Cart

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