Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Clonality
polyclonal
Host
Rabbit
Immunogen
TNF receptor-associated factor 1
Immunogen Region
TNF receptor-associated factor 1
Isotype
IgG
Molecular Weight
46 kDa
Reactivity
Human
Recommended Dilution
IHC: 1:20-1:200
Synonyms
EBI6, TRAF1
Uniprot
Q13077
Gene Id
26146
Research Area
Immunology, Signal Transduction, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10063.pdf" target="_blank">Data Sheet</ a>