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Home / Primary Antibodies / Polyclonal Antibodies

Tau Antibody - SPC-801

SKU : BHA11920146

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StressMarq Biosciences Inc.

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Mfr.No.	SPC-801, SPC-801D, SPC-801D-A390, SPC-801D-A488, SPC-801D-A594, SPC-801D-ALP, SPC-801D-APC, SPC-801D-BI, SPC-801D-FITC, SPC-801D-HRP, SPC-801D-PCP, SPC-801D-RPE, SPC-801S
Immunogen Species	Human
Alternative Names	Tau Antibody, Neurofibrillary tangle protein Antibody, MAPTL Antibody, Microtubule-associated protein tau Antibody, MTBT1 Antibody, Paired helical filament-tau Antibody, TAU Antibody, PHF-tau Antibody, MAPT Antibody, AI413597 antibody, AW045860 antibody, DDPAC antibody, FLJ31424 antibody, FTDP 17 antibody, G protein beta1/gamma2 subunit interacting factor 1 antibody, MAPT antibody, MAPTL antibody, MGC134287 antibody, MGC138549 antibody, MGC156663 antibody, Microtubule associated protein tau antibody, Microtubule associated protein tau isoform 4 antibody, Microtubule-associated protein tau antibody, MSTD antibody, Mtapt antibody, MTBT1 antibody, MTBT2 antibody, Neurofibrillary tangle protein antibody, Paired helical filament tau antibody, Paired helical filament-tau antibody, PHF tau antibody, PHF-tau antibody, PPND antibody, PPP1R103 antibody, Protein phosphatase 1, regulatory subunit 103 antibody, pTau antibody, RNPTAU antibody, TAU antibody, TAU_HUMAN antibody, Tauopathy and respiratory failure, included antibody
Categories	Antibodies
Cellular Localization	Cytoskeleton, Plasma Membrane, Cell Membrane, Peripheral Membrane Protein, Cytoplasmic Side, Cytosol, Axon, Microtubule, Microtubule Associated Complex, Tubulin Complex, Nucleus, Nuclear Periphery, Nuclear Speck, Axolemma Plasma Membrane, Axolemma, Cytoplasm, Cell Body, Cytoplasmic Ribonucleoprotein Granule, Dendrite, Growth Cone, Neurofibrillary Tangle, Neuronal Cell Body
Certificate Of Analysis	A 1:1000 dilution of SPC-801 was sufficient for detection of Tau in 10 ug of human SH-SY5Y cell lysate cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Tau Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide from the full length of Human Tau, Homo Sapiens (Human)
Immunogen Region	Recombinant Human Tau 2NR4 P301S Fibril
Launch Date	2018/11/21
Net Weight (g)	0.1
Reactivity	Human, Mouse
Species Reactivity Medium	Mouse, Human
Tissue Specificity	Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Swissprot	P10636
Gene Id	4137
Target	Tau
Research Area	Tangles & Tau, Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Cytoskeleton

Concentration	1 mg/ml
Purification	Protein A Purified
Scientific Background	Alzheimer s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~45.8kda.
Storage Buffer	PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, WB, IHC
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. www.alz.org/alzheimers-dementia/facts-figures 2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146148 (1907) 3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497. 4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18. 5. Guo, J. and Lee, M.Y. (2013). FEBS Lett. 587(6): 717-723. 6. Alberici, A. et al. (2004). J Neurol Neurosurg Psychiatry. 75:1607-1610.

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Combination SKU	Supplier No.	Conjugate	Size	Your price	Quantity
BHA11920146-1	SPC-801D	Unconjugated	100 ug	$330		Add to Cart
BHA11920146-2	SPC-801D-A390	ATTO 390	100 ug	$384		Add to Cart
BHA11920146-3	SPC-801D-A488	ATTO 488	100 ug	$383		Add to Cart
BHA11920146-4	SPC-801D-A594	ATTO 594	100 ug	$383		Add to Cart
BHA11920146-5	SPC-801D-ALP	Alkaline Phosphatase	100 ug	$376		Add to Cart
BHA11920146-6	SPC-801D-APC	APC	100 ug	$382		Add to Cart
BHA11920146-7	SPC-801D-BI	Biotin	100 ug	$378		Add to Cart
BHA11920146-8	SPC-801D-FITC	FITC	100 ug	$374		Add to Cart
BHA11920146-9	SPC-801D-HRP	HRP	100 ug	$370		Add to Cart
BHA11920146-10	SPC-801D-PCP	PerCP	100 ug	$382		Add to Cart
BHA11920146-11	SPC-801D-RPE	RPE	100 ug	$380		Add to Cart
BHA11920146-12	SPC-801S	Unconjugated	12 ug	$44		Add to Cart

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