Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.
Clonality
polyclonal
Host
Rabbit
Immunogen
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
Immunogen Region
TGF-beta-actIVated kinase 1 and MAP3K7-binding protein 3
Isotype
IgG
Molecular Weight
75-100 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:100
Synonyms
Mitogen-activated protein kinase kinase kinase 7-interacting protein 3,NF-kappa-B-activating protein 1, TAK1-binding protein 3, MAP3K7IP3
Uniprot
Q8N5C8
Gene Id
912
Research Area
Immunology
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:20-1:100
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10439.pdf" target="_blank">Data Sheet</ a>