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Home / Primary Antibodies / Polyclonal Antibodies

STAT1 antibody

SKU : BHA10809974

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Mfr.No.	FNab09985
Background	Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Clonality	polyclonal
Host	Rabbit
Immunogen	signal transducer and activator of transcription 1, 91kDa
Immunogen Region	signal transducer and actIVator of transcription 1, 91kDa
Isotype	IgG
Molecular Weight	84 kDa
Reactivity	Human, Rat
Recommended Dilution	WB: 1:500-1:2000; IHC: 1:50-1:500
Synonyms	ISGF 3, STAT1, STAT91

Uniprot	P42224
Gene Id	6772
Research Area	Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:500

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09985.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809974	FNab09985	100ug	$260		Add to Cart

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