Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors(By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification(By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter(By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'-AACAAT-3'.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.
Host
Rabbit
Immunogen
SRY(sex determining region Y)-box 7
Isotype
IgG
Molecular Weight
42-45 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Antigen
SOX7
Uniprot
Q9BT81
Gene Id
83595
Research Area
Epigenetics, Stem Cells, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)