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Home / Primary Antibodies / Polyclonal Antibodies

SOCS3 antibody

SKU : BHA10808092

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Mfr.No.	FNab08100
Alternative Names	CIS3 ; SSI3
Background	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo(By similarity). Probable substrate recognition component of a SCF-like ECS(Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST(By similarity).
Categories	Primary Antibodies
Cellular Localization	Cytoplasm
Clonality	polyclonal
Description	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).
Host	Rabbit
Immunogen	suppressor of cytokine signaling 3
Isotype	IgG
Molecular Weight	30 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	cytoplasm
Synonyms	ATOD4, CIS 3, CIS3, Cish3, SOCS 3, SOCS3, SSI 3, SSI3, STAT induced STAT inhibitor 3

Uniprot	O14543
Gene Id	9021
Research Area	Developmental biology, Signal Transduction
Weight	25kDa,observed 30kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC, WB, IF, IP

Description

ELISA ; IHC ; WB ; IF ; IP

Dilution

WB	1:200-1:2000
IP	1:200-1:2000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Manual	FNab08100.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808092	FNab08100	100ug	$260		Add to Cart

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