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Home / Primary Antibodies / Polyclonal Antibodies

SIX2 antibody

SKU : BHA10807879

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Mfr.No.	FNab07887
Background	Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development(By similarity). Plays a role in cell proliferation and migration.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration.
Host	Rabbit
Immunogen	SIX homeobox 2
Isotype	IgG
Molecular Weight	35 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Homeobox protein SIX2, Sine oculis homeobox homolog 2, SIX homeobox 2, SIX2

Antigen	SIX2
Uniprot	Q9NPC8
Gene Id	10736
Research Area	Developmental biology, Stem Cells, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IF, IP, WB
Description	ELISA ; IHC ; IF ; IP ; WB
Tested Application	WB: 1:500-1:1000; IP: 1:500-1:1000; IF: 1:20-1:200

Manual	FNab07887.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807879	FNab07887	100ug	$260		Add to Cart

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