Negative regulator of B-cell activation. Down-regulates cell proliferation(in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation(By similarity).
Categories
Primary Antibodies
Clonality
polyclonal
Description
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
Host
Rabbit
Immunogen
SAM domain, SH3 domain and nuclear localization signals 1
Isotype
IgG
Molecular Weight
42-50 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
HACS1
Uniprot
Q9NSI8
Gene Id
64092
Research Area
stem cells
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)