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Home / Primary Antibodies / Polyclonal Antibodies

PLC ?2 (phospho Tyr753) Rabbit pAb

SKU : BHA15200478

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ELK Biotechnology

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Mfr.No.	ES1477
Antigen	PLC ?2 (phospho Tyr753)
Background	Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC ?1, PLC ?2, PLC ?3, PLC ?4, PLC ?1, PLC ?2, PLC ?1, PLC ?2 and PLC e. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC ?2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR ? chain), which bind to its C-terminal SH2 domain. PLC ?1 associates with Syk in B cells, but PLC ?2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC ?2. In addition, Btk can induce PLC ?2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Clonality	Polyclonal
Conjugate	Unconjugate
Host	Rabbit
Immunogen	Synthesized peptide derived from human PLC ?2 around the phosphorylation site of Y753.
Isotype	IgG
Reactivity	Mouse, Rat, Human

Gene Id	5336

Concentration	1mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ELISA

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA15200478	ES1477	50µl	$148		Add to Cart
BHA15200478	ES1477	100µl	$248		Add to Cart

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