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Home / Primary Antibodies / Polyclonal Antibodies

P62/SQSTM1 antibody

SKU : BHA10806078

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Mfr.No.	FNab06086
Alternative Names	P62 ; sequestosome1 ; SQSTM1 ; Ubiquitinbindingproteinp62
Background	This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy, cell signaling pathways, and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate, p62 is degraded during the autophagic process, which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases, including Huntington's disease, Alzheimer's disease, Parkinson's disease in the brain, and nephropathic cystinosis in kidney (22074114, 22860231, 22714671). The molecular weight of p62 is predicted as 48/ 38 kDa, while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
Host	Rabbit
Immunogen	sequestosome 1
Isotype	IgG
Molecular Weight	65 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	1-240aa
Synonyms	P62, sequestosome 1, SQSTM1, Ubiquitin binding protein p62

Uniprot	Q13501
Gene Id	8878
Research Area	Cardiovascular, Metabolism, Signal Transduction, Neuroscience
Weight	48kDa,observed 62kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP, IF, FC

Description

ELISA ; WB ; IHC ; IP ; IF ; FC

Dilution

WB	1:1000-1:10000
IP	1:1000-1:10000
IHC	1:20-1:200
IF	1:20-1:200

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:20 - 1:100

Manual	FNab06086.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806078	FNab06086	100ug	$260		Add to Cart

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