Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
Host
Rabbit
Immunogen
mitochondrial tumor suppressor 1
Isotype
IgG
Molecular Weight
120kd,180kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
ATBP, ATIP, GK1, KIAA1288, MTSG1
Antigen
MTUS1
Uniprot
Q9ULD2
Gene Id
57509
Research Area
Epigenetics, Cancer
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)