Rabbit Anti-Human MAPK4 (pSer186) Polyclonal

Mfr.No.	SPC-976, SPC-976D, SPC-976D-A390, SPC-976D-A488, SPC-976D-A594, SPC-976D-BI, SPC-976D-FITC
Immunogen Species	Human
Alternative Names	ERK4 Antibody, ERK3 Antibody, ERK3 related Antibody, MAPK4 Antibody, Extracellular signal regulated kinase 4 Antibody, MAP kinase 4 Antibody, MAP kinase isoform p63 Antibody, MAPK4 Antibody, Mitogen activated protein kinase 4 Antibody, MK04_HUMAN Antibody, p63MAPK Antibody, PRKM4 Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Nucleus
Certificate Of Analysis	A 1:250 dilution of SPC-976 was sufficient for detection of MAPK4 (pSer186) in 10 ug of mouse brain lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human MAPK4 (pSer186) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Ser186 of human MAPK4 (AA183-190), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Ser186 of human MAPK4 (AA183-190)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Highly expressed in heart and brain.

Swissprot	P31152
Accession Number	NP_002738
Gene Id	5596
Target	MAPK4 (pSer186)
Research Area	Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Cancer

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Highly expressed in heart and brain.
Scientific Background	MAPK4 is a protein-serine/threonine kinase that phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. MAPK4 may promote entry in the cell cycle.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 62.623 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11912384-1	SPC-976D	Unconjugated	100 ul	$331	Add to Cart
BHA11912384-2	SPC-976D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11912384-3	SPC-976D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11912384-4	SPC-976D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11912384-5	SPC-976D-BI	Biotin	100 ul	$380	Add to Cart
BHA11912384-6	SPC-976D-FITC	FITC	100 ul	$375	Add to Cart

MAPK4 Antibody (pSer186) - SPC-976