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Home / Primary Antibodies / Polyclonal Antibodies

LITAF antibody

SKU : BHA10804790

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Mfr.No.	FNab04798
Alternative Names	PIG7 ; SIMPLE
Background	Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression.
Host	Rabbit
Immunogen	lipopolysaccharide-induced TNF factor
Isotype	IgG
Molecular Weight	20 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	PIG7, SIMPLE

Uniprot	Q99732
Gene Id	9516
Research Area	Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04798.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804790	FNab04798	100ug	$240		Add to Cart

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