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Home / Primary Antibodies / Polyclonal Antibodies

IL12B antibody

SKU : BHA10804212

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Mfr.No.	FNab04219
Alternative Names	NKSF2
Background	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Host	Rabbit
Immunogen	interleukin 12B
Isotype	IgG
Molecular Weight	37 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	CLMF, CLMF p40, CLMF2, IL 12 subunit p40, IL 12B, IL12B, Interleukin 12 subunit beta, NKSF, NKSF2

Uniprot	P29460
Gene Id	3593
Research Area	Developmental biology, Immunology, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500-1:2000

Manual	FNab04219.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804212	FNab04219	100ug	$280		Add to Cart

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