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Home / Primary Antibodies / Polyclonal Antibodies

HSPB2 (MKBP) Antibody - SPC-194

BHA11907278
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Email
[email protected]
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Swissprot Q16082
Accession Number NP_001532.1
Gene Id 3316
Target HSPB2
Research Area Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking
Buffer PBS, 50% glycerol, 0.02% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein A Purified
Scientific Background HSPB2, also known as MKBP is the most divergent member of the sHSP family with only 30% sequence identity to all other mammalian sHSPS (1). MKBP is known to associate specifically with myotonic dystrophy protein kinase (DMPK) in skeletal muscle. MKBP enhances the kinase activity of DMPK and protects it from heat-induced activation. MKBP also shows a unique nature compared to other sHSPs, in that the expression of MKBP is not induced by heat shock (2). In unstressed skeletal muscle, MKBP forms large oligomeric complexes with HSPB3 in the cytosol which are localized on mitochondria and the neuromuscular junction (1, 3). During stress, these complexes dissolve and MKBP's localization to mitochondria increases, leading to increased cell survival. Pinz et al. tried to find a distinct role for MKBP in terms of cardiac mechanics and finds that it is required for normal systolic performance and normal cardiac energetic (1). HSPB2 has also been found to be expressed in several cancer cell lines, including human breast cancer, suggesting that MKBP may be an important factor in tumor transformation and metastasis (4).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~27kDa.
Storage -20ºC
Storage Buffer PBS, 50% glycerol, 0.02% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Pinz I., et al. (2008) FASEB J. 22: 84-92.

2. Suzuki A., et al. (1998) J Cell Bio. 140(5): 1113-1124.

3. Sugiyama Y., et al. (2000) J Biol Chem. 275: 1095-1104.

4. Oshita S.E., et al. (2010) Breast Cancer Res Treat. Epub: 20087649.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11907278-1 SPC-194D Unconjugated 100 ug $330
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BHA11907278-2 SPC-194C Unconjugated 25 ug $139
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BHA11907278-3 SPC-194D-A390 ATTO 390 100 ug $384
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BHA11907278-4 SPC-194D-A488 ATTO 488 100 ug $383
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BHA11907278-5 SPC-194D-A594 ATTO 594 100 ug $383
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BHA11907278-6 SPC-194D-ALP Alkaline Phosphatase 100 ug $376
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BHA11907278-7 SPC-194D-APC APC 100 ug $382
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BHA11907278-8 SPC-194D-BI Biotin 100 ug $378
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BHA11907278-9 SPC-194D-FITC FITC 100 ug $374
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BHA11907278-10 SPC-194D-HRP HRP 100 ug $370
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BHA11907278-11 SPC-194D-PCP PerCP 100 ug $382
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BHA11907278-12 SPC-194D-RPE RPE 100 ug $380
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BHA11907278-13 SPC-194S Unconjugated 12 ug $44
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