Rabbit Anti-Human FGFR3 (pTyr647 + pTyr648) Polyclonal

Mfr.No.	SPC-983, SPC-983D, SPC-983D-A390, SPC-983D-A488, SPC-983D-A594, SPC-983D-BI, SPC-983D-FITC
Immunogen Species	Human
Alternative Names	ACH Antibody, CD333 Antibody, FGFR3 Antibody, CEK2 Antibody, Fibroblast growth factor receptor 3 Antibody, Heparin binding growth factor receptor Antibody, HSFGFR3EX Antibody, Hydroxyaryl protein kinase Antibody, JTK4 Antibody, MFR 3 Antibody, SAM 3 Antibody, Tyrosine kinase JTK 4 Antibody, Tyrosine kinase JTK4 Antibody, Z FGFR 3 Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Cell Membrane, Cytoplasmic Vesicle
Certificate Of Analysis	A 1:250 dilution of SPC-983 was sufficient for detection of FGFR3 (pTyr647 + pTyr648) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human FGFR3 (pTyr647 + pTyr648) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Tyr647 and Tyr648 of human FGFR3 (AA644-651), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Tyr647 and Tyr648 of human FGFR3 (AA644-651)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Expressed in brain, kidney and testis

Swissprot	P22607
Accession Number	NP_000133
Gene Id	2261
Target	FGFR3 (pTyr647 + pTyr648)
Research Area	Cardiovascular System, Angiogenesis, Cardiovascular Growth Factors, FGF, Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Receptor Tyrosine Kinases, Neurogenesis, Cancer, Stem Cells, Lineage Markers, Ectoderm, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Expressed in brain, kidney and testis
Scientific Background	FGFR3 is a receptor-tyrosine kinase that is activated upon binding fibroblast growth factor (FGF). Extracellular ligand binding induces homo- or hetero- dimerization of FGFR to activate signalling. FGFRs have an essential role in regulating cellular differentiation, proliferation and apoptosis. The FGFR3 isoform is specifically involved in chondrocyte development which is physiologically linked to normal skeleton development. Defects in FGFR3 can lead to dwarfism. Overexpressed FGFR3 can promote activation of SHP2 and STAT signalling pathways.Mutations which promote constitutive dimerization of FGFR and kinase activation or impairs internalization and degradation of the receptor have been observed in bladder, skin and oral cancers.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 87.710 (110-120) kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11912510-1	SPC-983D	Unconjugated	100 ul	$331	Add to Cart
BHA11912510-2	SPC-983D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11912510-3	SPC-983D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11912510-4	SPC-983D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11912510-5	SPC-983D-BI	Biotin	100 ul	$380	Add to Cart
BHA11912510-6	SPC-983D-FITC	FITC	100 ul	$375	Add to Cart

FGFR3 Antibody (pTyr647 + pTyr648) - SPC-983