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Home / Primary Antibodies / Polyclonal Antibodies

FGFR-4 (phospho Tyr642) Rabbit pAb

SKU : BHA15204252

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ELK Biotechnology

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Mfr.No.	ES5251
Background	The protein encoded by FGFR4 (fibroblast growth factor receptor 4) is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of FGFR4, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Clonality	Polyclonal
Host	Rabbit
Immunogen	Synthesized peptide derived from human FGFR-4 around the phosphorylation site of Y642.
Isotype	IgG
Reactivity	Human, Mouse, Rat

Gene Id	2264

Concentration	1mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA15204252	ES5251	50µl	$148		Add to Cart
BHA15204252	ES5251	100µl	$248		Add to Cart

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