DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
Categories
Primary Antibodies
Clonality
polyclonal
Description
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
Host
Rabbit
Immunogen
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
Isotype
IgG
Molecular Weight
180kd
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
PICH
Antigen
ERCC6L
Uniprot
Q2NKX8
Gene Id
54821
Research Area
Epigenetics, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)