Rabbit Anti-Human DOK3 (pTyr398) Polyclonal

Mfr.No.	SPC-958, SPC-958D, SPC-958D-A390, SPC-958D-A488, SPC-958D-A594, SPC-958D-BI, SPC-958D-FITC
Immunogen Species	Human
Alternative Names	Docking protein 3 Antibody, DOK Like Protein Antibody, Dok3 Antibody, DOKL Pending Antibody, Downstream of tyrosine kinase 3 Antibody, p62 DOK Like Protein Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Cell Membrane
Certificate Of Analysis	A 1:250 dilution of SPC-958 was sufficient for detection of DOK3 (pTyr398) in 10 ug of HepG2 cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human DOK3 (pTyr398) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Tyr397 of human EML4 (AA395-401), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Tyr397 of human EML4 (AA395-401)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	Q7L591
Accession Number	NP_001138347
Gene Id	79930
Target	DOK3 (pTyr398)
Research Area	Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Cancer

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	DOK3 is a member of a class of docking proteins which contain multiple tyrosine residues and putative SH2 binding sites. DOK3 is an adapter involved in the recruitment of inhibitory molecules and is highly expressed in B cells and macrophages. Immunoreceptor-mediated cellular activation induces tyrosine phosphorylation of DOK3. Upon phosphorylation, DOK3 binds to 5' inositol phosphatase SHIP and the protein tyrosine kinase Csk. DOK3 may play a significant role in the negative regulation of immunoreceptor signaling in hemopoietic cells.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 53.288 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11912060-1	SPC-958D	Unconjugated	100 ul	$331	Add to Cart
BHA11912060-2	SPC-958D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11912060-3	SPC-958D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11912060-4	SPC-958D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11912060-5	SPC-958D-BI	Biotin	100 ul	$380	Add to Cart
BHA11912060-6	SPC-958D-FITC	FITC	100 ul	$375	Add to Cart

DOK3 Antibody (pTyr398) - SPC-958