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Home / Primary Antibodies / Polyclonal Antibodies

DKK1 antibody

SKU : BHA10802395

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Mfr.No.	FNab02401
Background	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Host	Rabbit
Immunogen	dickkopf homolog 1
Isotype	IgG
Molecular Weight	30-35 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Dickkopf 1, Dickkopf related protein 1, DKK 1, DKK1, hDkk 1, SK

Uniprot	O94907
Gene Id	22943
Research Area	Developmental biology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IHC
Description	ELISA ; WB ; IF ; IHC
Tested Application	WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802395	FNab02401	100ug	$240		Add to Cart

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