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Home / Primary Antibodies / Polyclonal Antibodies

Crk II (phospho Tyr221) Rabbit pAb

SKU : BHA15200449

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ELK Biotechnology

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Mfr.No.	ES1448
Antigen	Crk II (phospho Tyr221)
Background	The Crk family of adapter proteins including Crk-II, Crk-I, and Crk-L consist mostly of SH2 and SH3 domains. Through the interactions between SH2 domain and phosphotyrosine residues and/or between SH3 domain and proline-rich motifs, they are involved in a variety of signaling cascades. Crk I and Crk II are encoded by the same gene, which undergoes alternative splicing to yield these two proteins, but differ in their biological activities (2-4). Crk-II has less transforming activity than Crk-I, although both Crk-I and Crk-II bind to many tyrosine-phosphorylated proteins that bind to grb2 (2,4). In addition, Crk-II becomes rapidly tyrosine-phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) and might be involved in the IGF-I receptor signalling pathway.
Clonality	Polyclonal
Conjugate	Unconjugate
Host	Rabbit
Immunogen	Synthesized peptide derived from human Crk II around the phosphorylation site of Y221.
Isotype	IgG
Reactivity	Mouse, Rat, Monkey, Human

Gene Id	1398

Concentration	1mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Applications	WB, IF, ELISA

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA15200449	ES1448	50µl	$148		Add to Cart
BHA15200449	ES1448	100µl	$248		Add to Cart

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