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Home / Primary Antibodies / Polyclonal Antibodies

CD40 (phospho Thr254) Rabbit pAb

SKU : BHA15207068

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ELK Biotechnology

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Mfr.No.	ES8067
Antigen	CD40 (phospho Thr254)
Background	Resting B cells can be activated and clonally expanded into antibody-producing cells in response to a combination of cell contact and soluble signals provided by primed helper T (Th) cells. While cytokines IL-4 and IL-13 alone are inadequate for B cell activation, contact with Th cells seems to be sufficient for delivery of proliferative signals. A receptor ligand pair central to the transmission of this signal is CD40, expressed on the surface of B cells, together with CD40L, expressed on activated T cells. In the presence of such stimulus, IL-4 and IL-13 are capable of triggering immunoglobulin class switching and secretion of IgE. B cells are sensitive to these cytokines only subsequent to CD40/CD40L-driven DNA synthesis. A downstream mediator of the CD40 signaling pathway, designated CRAF, is a member of an expanding family of proteins that contain a conserved cysteine- and histidine-rich RING finger motif. Other members of the family include TRAF1 and TRAF2. The latter proteins have been shown to regulate TNF-R2 as well as CD40 signaling through activation of the NFkB family of transcription factors.
Clonality	Polyclonal
Conjugate	Unconjugate
Host	Rabbit
Immunogen	Synthesized peptide derived from human CD40 around the phosphorylation site of T254.
Isotype	IgG
Reactivity	Human, Mouse

Gene Id	958

Concentration	1mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA15207068	ES8067	50µl	$148		Add to Cart
BHA15207068	ES8067	100µl	$248		Add to Cart

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