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Home / Primary Antibodies / Polyclonal Antibodies

CD31 Antibody - SPC-1283

BHA11917298
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Email
[email protected]
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Swissprot P16284
Accession Number NP_000433.4
Gene Id 5175
Target CD31
Research Area Cell adhesion, Cardiovascular System, Blood, Cell Signaling, Angiogenesis, Cardiovascular Growth Factors, Angiogenic Factors, Stem Cells, Mesenchymal Stem Cells, MSC Surface Molecules, Hematopoietic Progenitors, T Lymphocytic Lineage, Myeloid, Monocytic Lineage, Neutrophil Lineage, Thrombocytic Lineage, Cardiovascular Markers, Endothelial Cells, Atherosclerosis, Vascular Inflammation, Leukocyte Recruitment, Cancer, Invasion/microenvironment, Immunology, Cell Type Markers, CD Markers, Lymphoid, Platelets, Cytoskeleton
Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Dilutions WB (1:2000), IHC (1:200), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U937 histiocytic lymphoma cell lines (at protein level).
Scientific Background CD31 is a 130-140 kD glycoprotein, also known as platelet endothelial cell adhesion molecule (PECAM-1), EndoCAM, and gpIIa. It is a member of the Ig superfamily, expressed on endothelial cells, platelets, granulocytes, monocytes/macrophages, dendritic cells, and T and B cell subsets, and is critical for cell-to-cell interactions. CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas. It is rarely found in some sarcomas, such as Kaposi's sarcoma, and carcinomas. The primary ligands for CD31 have been reported to be CD38 and the vitronectin receptor (alphav beta3 integrin, CD51/CD61). Other reported functions of CD31 are neutrophil emigration to sites of inflammation, and angiogenesis.
Shipping Temperature Blue Ice or 4°C
Specificity Detects endogenous levels of total CD31
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB, ICC/IF
Description WB ; IHC ; ICC ; IF
Dilution WB (1:2000), IHC (1:200), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press.

2. DeLisser HM, et al. 1994. Immunol. Today 15:490.

3. Newman PJ, et al. 1990. Science 247:1219.

4. Ganjei-Azar, Parvin (2007). Color Atlas of Immunocytochemistry in Diagnostic Cytology. (New York): Springer Science+Business Media, LLC. p. 47.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11917298-1 SPC-1283D Unconjugated 100 ul $286
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BHA11917298-2 SPC-1283D-A390 ATTO 390 100 ul $340
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BHA11917298-3 SPC-1283D-A488 ATTO 488 100 ul $339
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BHA11917298-4 SPC-1283D-A594 ATTO 594 100 ul $339
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BHA11917298-5 SPC-1283D-BI Biotin 100 ul $334
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BHA11917298-6 SPC-1283D-FITC FITC 100 ul $330
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