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Home / Primary Antibodies / Polyclonal Antibodies

c-Kit Antibody (Ser821+ Tyr823) - SPC-1003

BHA11912870
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Swissprot P10721
Accession Number NP_000213
Gene Id 3815
Target c-Kit (Ser821+ Tyr823)
Research Area Immunology, Cell Type Markers, CD Cytokines, Cancer, Tumor Biomarkers, Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Receptor Tyrosine Kinases, Stem Cells, Hematopoietic Progenitors, HP Surface Molecules, Myeloid Mast Cell Lineage, HP Markers, Germline Stem Cells, Embryonic Germ Cells, Oncoproteins, Tags and Cell Markers, Germ Cell Markers, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells
Scientific Background c-KIT is a receptor tyrosine kinase that plays an essential role in the regulation of cell survival and proliferation, especially hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and melanogenesis. Following activation by KITLG/SCF binding, it can activate the PLCG1, AKT1, RAS, and STAT pathways. Activation of PLCG1 can lead to increased calcium signalling. Mutations leading to constitutive kinase activity have been associated with gastrointestinal stromal tumour, testicular tumours, and acute myelogenous leukemia. The human proto-oncogene c-kit was first identified as the homolog of the feline sarcoma viral oncogene v-kit.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 109.865 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11912870-1 SPC-1003D Unconjugated 100 ul $331
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BHA11912870-2 SPC-1003D-A390 ATTO 390 100 ul $385
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BHA11912870-3 SPC-1003D-A488 ATTO 488 100 ul $384
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BHA11912870-4 SPC-1003D-A594 ATTO 594 100 ul $384
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BHA11912870-5 SPC-1003D-BI Biotin 100 ul $380
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BHA11912870-6 SPC-1003D-FITC FITC 100 ul $375
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