Rabbit Anti-Human BVR Polyclonal

Mfr.No.	SPC-214, SPC-214D, SPC-214D-A390, SPC-214D-A488, SPC-214D-A594, SPC-214D-ALP, SPC-214D-APC, SPC-214D-BI, SPC-214D-FITC, SPC-214D-HRP, SPC-214D-PCP, SPC-214D-RPE, SPC-214S
Immunogen Species	Human
Alternative Names	Biliverdin Reductase Antibody, BIEA_HUMAN Antibody, Biliverdin IX alpha reductase Antibody, Biliverdin reductase A Antibody, Biliverdin-IX alpha-reductase Antibody, BLVR A Antibody, BLVR Antibody, Blvra Antibody, BVR A Antibody, BVRA Antibody, Zinc metalloprotein Antibody, zinc-metalloprotein Antibody
Categories	Antibodies
Cellular Localization	Cytoplasm
Certificate Of Analysis	1 ug/ml of SPC-214 was sufficient for detection of BVR in 10 ug of mixed human cell line lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human BVR Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Human native full-length BVR, Homo Sapiens (Human)
Immunogen Region	Human native full-length BVR
Launch Date	2014/05/07
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	P53004
Accession Number	NP_000703.2
Gene Id	644
Target	BVR
Research Area	Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Oxidative Stress, Metabolism, Redox Metabolism

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:2000), ICC/IF (1:120), IP (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Biliverdin Reductase (BVR) is a cytoplasmic enzyme that catalyzes the conversion of biliverdin to bilirubin by converting a double bond between the second and third pyrrole ring into a single bond (1). It is ubiqutiously expressed in all tissues- it occurs in cells and brain regiuons that already display HO-1 and HO-2, but also in regions and cell types with potential to induce stress proteins. It is unique among all enzymes in having two pH optima, using a different cofactor at each pH range, NADH at pH7.0 and NADPH at pH8.7 (2). It is not inactivated by heat shock, and have shown to abate inflammation, oxidative stress and apoptosis (3).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~40-42kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, IP, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF ; IP
Dilution	WB (1:2000), ICC/IF (1:120), IP (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Singleton J.W., Laster L. (1965). J Biol Chem. 240: 4780-4789. 2. Kutty R.K., Maines M.D. (1981) J Biol Chem. 256: 3956-3962. 3. Mishra M., Ndisand J.F. (2014) Curr Pharm Des. 20(9): 1370-1391.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907602-1	SPC-214D	Unconjugated	100 ug	$331	Add to Cart
BHA11907602-2	SPC-214D-A390	ATTO 390	100 ug	$385	Add to Cart
BHA11907602-3	SPC-214D-A488	ATTO 488	100 ug	$384	Add to Cart
BHA11907602-4	SPC-214D-A594	ATTO 594	100 ug	$384	Add to Cart
BHA11907602-5	SPC-214D-ALP	Alkaline Phosphatase	100 ug	$377	Add to Cart
BHA11907602-6	SPC-214D-APC	APC	100 ug	$383	Add to Cart
BHA11907602-7	SPC-214D-BI	Biotin	100 ug	$380	Add to Cart
BHA11907602-8	SPC-214D-FITC	FITC	100 ug	$375	Add to Cart
BHA11907602-9	SPC-214D-HRP	HRP	100 ug	$371	Add to Cart
BHA11907602-10	SPC-214D-PCP	PerCP	100 ug	$383	Add to Cart
BHA11907602-11	SPC-214D-RPE	RPE	100 ug	$381	Add to Cart
BHA11907602-12	SPC-214S	Unconjugated	12 ug	$44	Add to Cart

BVR Antibody - SPC-214