Rabbit Anti-Human BIM/BOD (IN2) Polyclonal

Mfr.No.	SPC-164, SPC-164D, SPC-164C, SPC-164D-A390, SPC-164D-A488, SPC-164D-A594, SPC-164D-ALP, SPC-164D-APC, SPC-164D-BI, SPC-164D-FITC, SPC-164D-HRP, SPC-164D-PCP, SPC-164D-RPE
Immunogen Species	Human
Alternative Names	BCL2 like protein 11 Antibody, Bcl2 interacting mediator of cell death Antibody, Bcl2 interacting protein Bim Antibody, BCL@ like 11 Antibody, BAM Antibody, BimEl Antibody, BimL Antibody, BOD Antibody, BIM beta 6 Antibody, BIM Beta7 Antibody, BIM alpha 3 Antibody, BIM alpha4 Antibody, BIM alpha5 Antibody, BIM alpha6 Antibody
Categories	Antibodies
Cellular Localization	Mitochondrion, Endomembrane System
Certificate Of Analysis	2.5 ug/ml of SPC-164 was sufficient for detection of Bim in 20 ug of K562 cell lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human BIM/BOD (IN2) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Internal central amino acids of human Bim, Homo Sapiens (Human)
Immunogen Region	Peptide corresponding to amino acids near the center of human BIM.
Launch Date	2007/06/01
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	O43521
Accession Number	NP_619527.1
Gene Id	10018
Target	BIM
Research Area	Cancer, Apoptosis, Intracellular, Neurodegeneration, Alzheimer's Disease, Immunology, Innate Immunity, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, MAPK Pathway, Invasion/microenvironment, Tumor Biomarkers, Oncoproteins, Metabolism, Metabolism processes, Neuroscience, Macrophage

Buffer	PBS, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:400), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Protein A Purified
Scientific Background	Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bim or BOD in human, mouse and rat (1,2). Bim/BOD interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Bim/BOD induces apoptosis. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines (1,2).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~23kDa.
Storage	-20ºC
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:400), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. O'Connor L., Strasser A., O'Reilly L.A., et al. (1998) EMBO J. 17:384-395. 2. Hsu S.Y., Lin P., and Hsueh A.J. (1998) Mol. Endocrinol. 12:1432-40.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11906865-1	SPC-164D	Unconjugated	100 ug	$330	Add to Cart
BHA11906865-2	SPC-164C	Unconjugated	25 ug	$156	Add to Cart
BHA11906865-3	SPC-164D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11906865-4	SPC-164D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11906865-5	SPC-164D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11906865-6	SPC-164D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11906865-7	SPC-164D-APC	APC	100 ug	$382	Add to Cart
BHA11906865-8	SPC-164D-BI	Biotin	100 ug	$378	Add to Cart
BHA11906865-9	SPC-164D-FITC	FITC	100 ug	$374	Add to Cart
BHA11906865-10	SPC-164D-HRP	HRP	100 ug	$370	Add to Cart
BHA11906865-11	SPC-164D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11906865-12	SPC-164D-RPE	RPE	100 ug	$380	Add to Cart

BIM/BOD (IN2) Antibody - SPC-164