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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SREBP2/SREBF2 Antibody Picoband®

SKU : BHA21003894

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Mfr.No.	A01678-2, A01678-2-10ug, A01678-2-Biotin, A01678-2-Cy3, A01678-2-Dylight488, A01678-2-Dylight550, A01678-2-Dylight594, A01678-2-FITC, A01678-2-HRP, A01678-2-APC, A01678-2-PE, A01678-2-iFluor647, A01678-2-carrier-free
Alternative Names	cholecystokinin B receptor
Background	Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alteate splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SREBP2/SREBF2 Antibody Picoband® catalog # A01678-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that acti
Host	Rabbit
Immunogen Region	E.coli-derived human SREBP2/SREBF2 recombinant protein (Position: R371-L409).
Isotype	Rabbit IgG
Molecular Weight	68 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Gastrin/cholecystokinin type B receptor; CCK-B receptor; CCK-BR; Cholecystokinin-2 receptor; CCK2-R; CCKBR; CCKRB
Tissue Specificity	Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q12772
Gene Id	6721
Gene Name	SREBF2
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human, Rat ELISA, 0.1-0.5 ug/ml, -

Reference	1. Brown, M. S., Ye, J., Goldstein, J. L. HDL miR-ed down by SREBP introns. Science 328: 1495-1496, 2010. 2. DeBose-Boyd, R. A., Brown, M. S., Li, W.-P., Nohturfft, A., Goldstein, J. L., Espenshade, P. J. Transport-dependent proteolysis of SREBP: relocation of Site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi. Cell 99: 703-712, 1999. 3. Hua, X., Wu, J., Goldstein, J. L., Brown, M. S., Hobbs, H. H. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13. Genomics 25: 667-673, 1995.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003894-1	A01678-2	-	100 ug	$370		Add to Cart
BHA21003894-2	A01678-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003894-3	A01678-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003894-4	A01678-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003894-5	A01678-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003894-6	A01678-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003894-7	A01678-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003894-8	A01678-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003894-9	A01678-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003894-10	A01678-2-APC	APC	100 ug	$670		Add to Cart
BHA21003894-11	A01678-2-PE	PE	100 ug	$670		Add to Cart
BHA21003894-12	A01678-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003894-13	A01678-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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