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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Slc25a1 Antibody Picoband®

SKU : BHA21002944

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Mfr.No.	A05995-2, A05995-2-10ug, A05995-2-Biotin, A05995-2-Cy3, A05995-2-Dylight488, A05995-2-Dylight550, A05995-2-Dylight594, A05995-2-FITC, A05995-2-HRP, A05995-2-APC, A05995-2-PE, A05995-2-iFluor647, A05995-2-carrier-free
Alternative Names	solute carrier family 25 member 1
Background	Tricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by the SLC25A1 gene. It is mapped to 22q11.21. This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Slc25a1 Antibody Picoband® catalog # A05995-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Impo
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Slc25a1, which shares 93.3% amino acid (aa) sequence identity with both mouse and rat Slc25a1.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Tricarboxylate transport protein, mitochondrial; Citrate transport protein; CTP; Solute carrier family 25 member 1; Tricarboxylate carrier protein; SLC25A1; SLC20A3
Tissue Specificity	Detected in brain. Detected at very much lower levels in heart, lung, placenta and skeletal muscle. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Uniprot	P53007
Gene Id	6576
Gene Name	SLC25A1
Subcellular Location	Mitochondrion inner membrane. Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br>

Reference	1. Chaouch, A., Porcelli, V., Cox, D., Edvardson, S., Scarcia, P., De Grassi, A., Pierri, C. L., Cossins, J., Laval, S. H., Griffin, H., Muller, J. S., Evangelista, T., and 13 others. Mutations in the mitochondrial citrate carrier SLC25A1 are associated with impaired neuromuscular transmission. J. Neuromusc. Dis. 1: 75-90, 2014.<br /><br />2. Edvardson, S., Porcelli, V., Jalas, C., Sioferman, D., Kelner, Y., Shaaq, A., Korman, S. H., Pierri, C. L., Scarcia, P., Fraenkel, N. D., Segel, R., Schechter, A., Frumkin, A., Pines, O., Saada, A., Palmieri, ., Elpeleg, O. Agenesis of corpus callosum and optic nerve hypoplasia due to mutations in SLC25A1 encoding the mitochondrial citrate transporter. J. Med. Genet. 50: 240-245, 2013. <br /><br />3. Goldmuntz, E., Wang, Z., Roe, B. A., Budarf, M. L. Cloning, genomic organization, and chromosomal localization of human citrate transport protein to the DiGeorge/velocardiofacial syndrome minimal critical region. Genomics 33: 271-276, 1996.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002944-1	A05995-2	-	100 ug	$370		Add to Cart
BHA21002944-2	A05995-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002944-3	A05995-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002944-4	A05995-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002944-5	A05995-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002944-6	A05995-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002944-7	A05995-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002944-8	A05995-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002944-9	A05995-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002944-10	A05995-2-APC	APC	100 ug	$670		Add to Cart
BHA21002944-11	A05995-2-PE	PE	100 ug	$670		Add to Cart
BHA21002944-12	A05995-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002944-13	A05995-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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