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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Six3 Antibody Picoband®

SKU : BHA21001278

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Mfr.No.	A02604, A02604-10ug, A02604-Biotin, A02604-Cy3, A02604-Dylight488, A02604-Dylight550, A02604-Dylight594, A02604-FITC, A02604-HRP, A02604-APC, A02604-PE, A02604-iFluor647, A02604-carrier-free
Alternative Names	Homeobox protein SIX3
Background	Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene. This gene encodes a member of the sine oculishomeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in SIX3 are the cause of a severe brain malformation, called holoprosencephaly type 2 (HPE2). In HPE2, the brain fails to separate into two hemispheres during early embryonic development, leading to eye and brain malformations, which result in serious facial abnormalities. A mutant zebrafish knockout model has been developed, in which the anterior part of the head was missing due to the atypical increase of Wnt1 activity. When injected with SIX3, these zebrafish embryos were able to successfully develop a normal forebrain. When SIX3 was tued off in mice, resulting in a lack of retina formation due to excessive expression of Wnt8b in the region where the forebrain normally develops. Both of these studies demonstrate the importance of SIX3 activity in brain and eye development.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Six3 Antibody Picoband® catalog # A02604. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intratha
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human Six3, different from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	35 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Homeobox protein SIX3;Sine oculis homeobox homolog 3;SIX3;
Tissue Specificity	Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	O95343
Gene Id	6496
Gene Name	SIX3
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat, Human<br>

Reference	1. Lagutin OV, Zhu CC, Kobayashi D, Topczewski J, Shimamura K, Puelles L, Russell HR, McKinnon PJ, Solnica-Krezel L, Oliver G (Feb 2003). "Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development". Genes & Development. 17 (3): 36879.<br /><br />2. Lavado A, Lagutin OV, Oliver G (Feb 2008). "Six3 inactivation causes progressive caudalization and aberrant patteing of the mammalian diencephalon". Development. 135 (3): 44150.<br /><br />3. Liu W, Lagutin O, Swindell E, Jamrich M, Oliver G (Oct 2010). "Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate". The Joual of Clinical Investigation. 120 (10): 356877.<br /><br />4. Wallis DE, Roessler E, Hehr U, Nanni L, Wiltshire T, Richieri-Costa A, Gillessen-Kaesbach G, Zackai EH, Rommens J, Muenke M (Jun 1999). "Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly". Nature Genetics. 22 (2): 1968.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001278-1	A02604	100 ug	-	$370		Add to Cart
BHA21001278-2	A02604-10ug	10 ug	Sample	$99		Add to Cart
BHA21001278-3	A02604-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001278-4	A02604-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001278-5	A02604-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001278-6	A02604-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001278-7	A02604-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001278-8	A02604-FITC	100 ug	FITC	$570		Add to Cart
BHA21001278-9	A02604-HRP	100 ug	HRP	$570		Add to Cart
BHA21001278-10	A02604-APC	100 ug	APC	$670		Add to Cart
BHA21001278-11	A02604-PE	100 ug	PE	$670		Add to Cart
BHA21001278-12	A02604-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001278-13	A02604-carrier-free	100 ug	carrier-free	$370		Add to Cart

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