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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Sigma1-receptor/SIGMAR1 Antibody Picoband®

SKU : BHA21004064

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Mfr.No.	A02493-2, A02493-2-10ug, A02493-2-Biotin, A02493-2-Cy3, A02493-2-Dylight488, A02493-2-Dylight550, A02493-2-Dylight594, A02493-2-FITC, A02493-2-HRP, A02493-2-APC, A02493-2-PE, A02493-2-iFluor647, A02493-2-carrier-free
Alternative Names	Heat shock protein beta-8
Background	The sigma-1 receptor (sigma1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. In humans, the sigma1 receptor is encoded by the SIGMAR1 gene. This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alteative splicing of this gene results in transcript variants encoding distinct isoforms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Sigma1-receptor/SIGMAR1 Antibody Picoband® catalog # A02493-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Displays temperature-dependent chaperone activity.
Host	Rabbit
Immunogen Region	E.coli-derived human Sigma1-receptor/SIGMAR1 recombinant protein (Position: G1-H154).
Isotype	Rabbit IgG
Molecular Weight	25 kDa
Reactivity	Human, Monkey, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Heat shock protein beta-8;HspB8;Alpha-crystallin C chain;E2-induced gene 1 protein;Protein kinase H11;Small stress protein-like protein HSP22;HSPB8;CRYAC, E2IG1, HSP22;PP1629;
Tissue Specificity	Predominantly expressed in skeletal muscle and heart. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q99720
Gene Id	10280
Gene Name	SIGMAR1
Subcellular Location	Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ELISA
Description	Weste blot, 0.1-0.25 ug/ml, Human, Monkey, Mouse<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Al-Saif, A., Al-Mohanna, F., Bohlega, S. A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis. Ann. Neurol. 70: 913-919, 2011. <br /><br />2. Aydar, E., Palmer, C. P., Klyachko, V. A., Jackson, M. B. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 34: 399-410, 2002. <br /><br />3. Belzil, V. V., Daoud, H., Camu, W., Strong, M. J., Dion, P. A., Rouleau, G. A. Genetic analysis of SIGMAR1 as a cause of familial ALS with dementia. Europ. J. Hum. Genet. 21: 237-239, 2013.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004064-1	A02493-2	-	100 ug	$370		Add to Cart
BHA21004064-2	A02493-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21004064-3	A02493-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004064-4	A02493-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004064-5	A02493-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004064-6	A02493-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004064-7	A02493-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004064-8	A02493-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21004064-9	A02493-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21004064-10	A02493-2-APC	APC	100 ug	$670		Add to Cart
BHA21004064-11	A02493-2-PE	PE	100 ug	$670		Add to Cart
BHA21004064-12	A02493-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004064-13	A02493-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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