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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SGT1/ECD Antibody Picoband®

SKU : BHA21003342

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Mfr.No.	A00567-1, A00567-1-10ug, A00567-1-Biotin, A00567-1-Cy3, A00567-1-Dylight488, A00567-1-Dylight550, A00567-1-Dylight594, A00567-1-FITC, A00567-1-HRP, A00567-1-APC, A00567-1-PE, A00567-1-iFluor647, A00567-1-carrier-free
Alternative Names	ADAM metallopeptidase domain 10
Background	Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SGT1/ECD Antibody Picoband® catalog # A00567-1. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-\|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of sever
Host	Rabbit
Immunogen Region	E.coli-derived human ECD recombinant protein (Position: L50-N632).
Isotype	Rabbit IgG
Molecular Weight	73 kDa
Reactivity	Human, Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD156c; ADAM10; KUZ; MADM
Tissue Specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	O95905
Gene Id	11319
Gene Name	ECD
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Hartz, P. A. Personal Communication. Baltimore, Md. 7/9/2015.<br /><br />2. Kim, J. H., Gurumurthy, C. B., Band, H., Band, V. Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation. Biol. Chem. 391: 9-19, 2010. <br /><br />3. Sato, T., Jigami, Y., Suzuki, T., Uemura, H. A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae. Molec. Gen. Genet. 260: 535-540, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003342-1	A00567-1	-	100 ug	$370		Add to Cart
BHA21003342-2	A00567-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003342-3	A00567-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003342-4	A00567-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003342-5	A00567-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003342-6	A00567-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003342-7	A00567-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003342-8	A00567-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003342-9	A00567-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003342-10	A00567-1-APC	APC	100 ug	$670		Add to Cart
BHA21003342-11	A00567-1-PE	PE	100 ug	$670		Add to Cart
BHA21003342-12	A00567-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003342-13	A00567-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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