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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SGT1/ECD Antibody Picoband®

SKU : BHA21003855

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Mfr.No.	A00567-2, A00567-2-10ug, A00567-2-Biotin, A00567-2-Cy3, A00567-2-Dylight488, A00567-2-Dylight550, A00567-2-Dylight594, A00567-2-FITC, A00567-2-HRP, A00567-2-APC, A00567-2-PE, A00567-2-iFluor647, A00567-2-carrier-free
Alternative Names	ADAM metallopeptidase domain 10
Background	Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SGT1/ECD Antibody Picoband® catalog # A00567-2. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-\|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of sever
Host	Rabbit
Immunogen Region	E.coli-derived human SGT1/ECD recombinant protein (Position: L50-Q567).
Isotype	Rabbit IgG
Molecular Weight	80 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD156c; ADAM10; KUZ; MADM
Tissue Specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O95905
Gene Id	11319
Gene Name	ECD
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Hartz, P. A. Personal Communication. Baltimore, Md. 7/9/2015. 2. Kim, J. H., Gurumurthy, C. B., Band, H., Band, V. Biochemical characterization of human Ecdysoneless reveals a role in transcriptional regulation. Biol. Chem. 391: 9-19, 2010. 3. Sato, T., Jigami, Y., Suzuki, T., Uemura, H. A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae. Molec. Gen. Genet. 260: 535-540, 1999.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003855-1	A00567-2	-	100 ug	$370		Add to Cart
BHA21003855-2	A00567-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003855-3	A00567-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003855-4	A00567-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003855-5	A00567-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003855-6	A00567-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003855-7	A00567-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003855-8	A00567-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003855-9	A00567-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003855-10	A00567-2-APC	APC	100 ug	$670		Add to Cart
BHA21003855-11	A00567-2-PE	PE	100 ug	$670		Add to Cart
BHA21003855-12	A00567-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003855-13	A00567-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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