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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Serum Response Factor/SRF Antibody Picoband®

SKU : BHA21003387

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Mfr.No.	A00557-2, A00557-2-10ug, A00557-2-Biotin, A00557-2-Cy3, A00557-2-Dylight488, A00557-2-Dylight550, A00557-2-Dylight594, A00557-2-FITC, A00557-2-HRP, A00557-2-APC, A00557-2-PE, A00557-2-iFluor647, A00557-2-carrier-free
Alternative Names	protein tyrosine phosphatase, receptor type, C
Background	Serum response factor, also known as SRF, is a transcription factor protein. This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the teary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Serum Response Factor/SRF Antibody Picoband® catalog # A00557-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affec
Host	Rabbit
Immunogen Region	E.coli-derived human SRF recombinant protein (Position: K163-E508).
Isotype	Rabbit IgG
Molecular Weight	67 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD45; PTPRC; CD45
Tissue Specificity	Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	P11831
Gene Id	6722
Gene Name	SRF
Subcellular Location	Cell membrane. Single-pass type I membrane protein. Membrane raft.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Barron, M. R., Belaguli, N. S., Zhang, S. X., Trinh, M., Iyer, D., Merlo, X., Lough, J. W., Parmacek, M. S., Bruneau, B. G., Schwartz, R. J. Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes. J. Biol. Chem. 280: 11816-11828, 2005. <br /><br />2. Bell, R. D., Deane, R., Chow, N., Long, X., Sagare, A., Singh, I., Streb, J. W., Guo, H., Rubio, A., Van Nostrand, W., Miano, J. M., Zlokovic, B. V. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biol. 11: 143-153, 2009. <br /><br />3. Chang, J., Wei, L., Otani, T., Youker, K. A., Entman, M. L., Schwartz, R. J. Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading. Circulation 108: 407-413, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003387-1	A00557-2	-	100 ug	$370		Add to Cart
BHA21003387-2	A00557-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003387-3	A00557-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003387-4	A00557-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003387-5	A00557-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003387-6	A00557-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003387-7	A00557-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003387-8	A00557-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003387-9	A00557-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003387-10	A00557-2-APC	APC	100 ug	$670		Add to Cart
BHA21003387-11	A00557-2-PE	PE	100 ug	$670		Add to Cart
BHA21003387-12	A00557-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003387-13	A00557-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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