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Home / Primary Antibodies / Polyclonal Antibodies

Anti-SCOP/PHLPP1 Picoband® Antibody

SKU : BHA21002555

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Mfr.No.	A02430-1, A02430-1-10ug, A02430-1-Biotin, A02430-1-Cy3, A02430-1-Dylight488, A02430-1-Dylight550, A02430-1-Dylight594, A02430-1-FITC, A02430-1-HRP, A02430-1-APC, A02430-1-PE, A02430-1-iFluor647, A02430-1-carrier-free
Alternative Names	PH domain and leucine rich repeat protein phosphatase 1
Background	The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. It is mapped to 18q21.33. This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SCOP/PHLPP1 Picoband® Antibody catalog # A02430-1. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of P
Host	Rabbit
Immunogen Region	E.coli-derived human SCOP/PHLPP1 recombinant protein (Position: R1083-A1436).
Isotype	Rabbit IgG
Molecular Weight	140 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	PH domain leucine-rich repeat-containing protein phosphatase 1; Pleckstrin homology domain-containing family E member 1; PH domain-containing family E member 1; Suprachiasmatic nucleus circadian oscillatory protein; hSCOP; PHLPP1; KIAA0606; PHLPP; PLEKHE1; SCOP
Tissue Specificity	Monocyte/macrophage specific.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	O60346
Gene Id	23239
Gene Name	PHLPP1
Subcellular Location	Nucleus. Cytoplasm. Membrane. Peripheral membrane protein. Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5ug/ml, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Brognard, J., Sierecki, E., Gao, T., Newton, A. C. PHLPP and a second isoform, PHLPp2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molec. Cell 25: 917-931, 2007.<br /><br />2. Chen, H. H., Handel, N., Ngeow, J., Muller, J., Huhn, M., Yang, H.-T., Heindl, M., Berbers, R.-M., Hegazy, A. N., Kionke, J., Yehia, L., Sack, U., and 15 others. Immune dysregulation in patients with PTEN hamartoma tumor syndrome.: analysis of FOXP3 regulatory T cells. J. Allergy Clin. Immun. 139: 607-620, 2017.<br /><br />3. Cheng, H.-Y. M., Papp, J. W., Varlamova, O., Dziema, H., Russell, B., Curfman, J. P., Nakazawa, T., Shimizu, K., Okamura, H., Impey, S., Obrietan, K. microRNA modulation of circadian-clock period and entrainment. Neuron 54: 813-829, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002555-1	A02430-1	-	100 ug	$370		Add to Cart
BHA21002555-2	A02430-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002555-3	A02430-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002555-4	A02430-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002555-5	A02430-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002555-6	A02430-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002555-7	A02430-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002555-8	A02430-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002555-9	A02430-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002555-10	A02430-1-APC	APC	100 ug	$670		Add to Cart
BHA21002555-11	A02430-1-PE	PE	100 ug	$670		Add to Cart
BHA21002555-12	A02430-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002555-13	A02430-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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