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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Placental alkaline phosphatase (PLAP)/ALPP Antibody Picoband®

SKU : BHA21001017

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Mfr.No.	A01718, A01718-10ug, A01718-Biotin, A01718-Cy3, A01718-Dylight488, A01718-Dylight550, A01718-Dylight594, A01718-FITC, A01718-HRP, A01718-APC, A01718-PE, A01718-iFluor647, A01718-carrier-free
Alternative Names	Alkaline phosphatase, placental type
Background	Alkaline phosphatase, placental type also known as placental alkaline phosphatase (PLAP) is an allosteric enzyme that in humans is encoded by the ALPP gene. The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Placental alkaline phosphatase (PLAP)/ALPP Antibody Picoband® catalog # A01718. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human ALPP.
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alkaline phosphatase, placental type;3.1.3.1;Alkaline phosphatase Regan isozyme;Placental alkaline phosphatase 1;PLAP-1;ALPP;PLAP;
Tissue Specificity	Detected in placenta (at protein level). .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P05187
Gene Id	250
Gene Name	ALPP
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat <br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. "Entrez Gene: ALPP alkaline phosphatase, placental (Regan isozyme)".<br /><br />2. Hentho PS, Knoll BJ, Raducha M, Rothblum KN, Slaughter C, Weiss M, Lafferty MA, Fischer T, Harris H (Sep 1986). "Products of two common alleles at the locus for human placental alkaline phosphatase differ by seven amino acids". Proc Natl Acad Sci U S A. 83 (15): 5597601.<br /><br />3. Kam W, Clauser E, Kim YS, Kan YW, Rutter WJ (Feb 1986). "Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA". Proc Natl Acad Sci U S A. 82 (24): 87159.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001017-1	A01718	100 ug	-	$370		Add to Cart
BHA21001017-2	A01718-10ug	10 ug	Sample	$99		Add to Cart
BHA21001017-3	A01718-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001017-4	A01718-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001017-5	A01718-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001017-6	A01718-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001017-7	A01718-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001017-8	A01718-FITC	100 ug	FITC	$570		Add to Cart
BHA21001017-9	A01718-HRP	100 ug	HRP	$570		Add to Cart
BHA21001017-10	A01718-APC	100 ug	APC	$670		Add to Cart
BHA21001017-11	A01718-PE	100 ug	PE	$670		Add to Cart
BHA21001017-12	A01718-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001017-13	A01718-carrier-free	100 ug	carrier-free	$370		Add to Cart

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