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Home / Primary Antibodies / Polyclonal Antibodies

Anti-NGF Antibody Picoband®

SKU : BHA21003872

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Mfr.No.	A00341-3, A00341-3-10ug, A00341-3-Biotin, A00341-3-Cy3, A00341-3-Dylight488, A00341-3-Dylight550, A00341-3-Dylight594, A00341-3-FITC, A00341-3-HRP, A00341-3-APC, A00341-3-PE, A00341-3-iFluor647, A00341-3-carrier-free
Alternative Names	nerve growth factor
Background	Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons. It is mapped to 1p13.2. This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-NGF Antibody Picoband® catalog # A00341-3. Tested in ELISA, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, different
Host	Rabbit
Immunogen Region	E.coli-derived human NGF recombinant protein (Position: S122-D186).
Isotype	Rabbit IgG
Molecular Weight	27 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Beta-nerve growth factor; Beta-NGF; NGF; NGFB
Tissue Specificity	Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P01138
Gene Id	4803
Gene Name	NGF
Subcellular Location	Secreted. Endosome lumen.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Breakefield, X. O., Orloff, G., Castiglione, C., Coussens, L., Axelrod, F. B., Ullrich, A. Structural gene for beta-nerve growth factor not defective in familial dysautonomia. Proc. Nat. Acad. Sci. 81: 4213-4216, 1984. 2. Carrier, A., Rosier, M.-F., Guillemot, F., Goguel, A.-F., Pulcini, F., Beheim, A., Auffray, C., Devignes, M.-D. Integrated physical, genetic, and genic map covering 3 Mb around the human NGF gene (NGFB) at 1p13. Genomics 31: 80-89, 1996. 3. Carvalho, O. P., Thoton, G. K., Hertecant, J., Houlden, H., Nicholas, A. K., Cox, J. J., Rielly, M., Al-Gazali, L., Woods, C. G. A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy. J. Med. Genet. 48: 131-135, 2011.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003872-1	A00341-3	-	100 ug	$370		Add to Cart
BHA21003872-2	A00341-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003872-3	A00341-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003872-4	A00341-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003872-5	A00341-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003872-6	A00341-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003872-7	A00341-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003872-8	A00341-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003872-9	A00341-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003872-10	A00341-3-APC	APC	100 ug	$670		Add to Cart
BHA21003872-11	A00341-3-PE	PE	100 ug	$670		Add to Cart
BHA21003872-12	A00341-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003872-13	A00341-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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