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Home / Primary Antibodies / Polyclonal Antibodies

Anti-N Cadherin/CDH2 Antibody Picoband®

SKU : BHA21003117

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Mfr.No.	A01577-3, A01577-3-10ug, A01577-3-Biotin, A01577-3-Cy3, A01577-3-Dylight488, A01577-3-Dylight550, A01577-3-Dylight594, A01577-3-FITC, A01577-3-HRP, A01577-3-APC, A01577-3-PE, A01577-3-iFluor647, A01577-3-carrier-free
Alternative Names	protein phosphatase, Mg2+/Mn2+ dependent 1D
Background	N-cadherin (NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-, and R-cadherin and liver cell adhesion molecule (L-CAM). N-Cadherin,, also known as Cadherin-2, encodes a 907-amino acid protein that includes a 159-amino acid signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200 kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene (including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-N Cadherin/CDH2 Antibody Picoband® catalog # A01577-3. Tested in ELISA, Flow Cytometry, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation o
Host	Rabbit
Immunogen Region	E.coli-derived human N Cadherin/CDH2 recombinant protein (Position: E170-E266).
Isotype	Rabbit IgG
Molecular Weight	150 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Protein phosphatase 1D; Protein phosphatase 2C isoform delta; PP2C-delta; Protein phosphatase magnesium-dependent 1 delta; p53-induced protein phosphatase 1; PPM1D; WIP1
Tissue Specificity	Plasma.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	P19022
Gene Id	1000
Gene Name	CDH2
Subcellular Location	Nucleus. Cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human<br> Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Miyatani, S.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Takeichi, M. : Genomic structure and chromosomal mapping of the mouse N-cadherin gene. Proc. Nat. Acad. Sci. 89: 8443-8447, 1992. <br /><br />2. Walsh, F. S.; Barton, C. H.; Putt, W.; Moore, S. E.; Kelsell, D.; Spurr, N.; Goodfellow, P. N. : N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene. J. Neurochem. 55: 805-812, 1990. <br /><br />3. Togashi, H.; Abe, K.; Mizoguchi, A.; Takaoka, K.; Chisaka, O.; Takeichi, M. : Cadherin regulates dendritic spine morphogenesis. Neuron 35: 77-89, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003117-1	A01577-3	-	100 ug	$370		Add to Cart
BHA21003117-2	A01577-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003117-3	A01577-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003117-4	A01577-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003117-5	A01577-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003117-6	A01577-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003117-7	A01577-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003117-8	A01577-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003117-9	A01577-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003117-10	A01577-3-APC	APC	100 ug	$670		Add to Cart
BHA21003117-11	A01577-3-PE	PE	100 ug	$670		Add to Cart
BHA21003117-12	A01577-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003117-13	A01577-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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