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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IL6R Antibody Picoband®

SKU : BHA21001248

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Mfr.No.	A01425-1, A01425-1-10ug, A01425-1-Biotin, A01425-1-Cy3, A01425-1-Dylight488, A01425-1-Dylight550, A01425-1-Dylight594, A01425-1-FITC, A01425-1-HRP, A01425-1-APC, A01425-1-PE, A01425-1-iFluor647, A01425-1-carrier-free
Alternative Names	Interleukin-6 receptor subunit alpha
Background	Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alteatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IL6R Antibody Picoband® catalog # A01425-1. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hemat
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human IL6R.
Isotype	Rabbit IgG
Molecular Weight	52 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interleukin-6 receptor subunit alpha;IL-6 receptor subunit alpha;IL-6R subunit alpha;IL-6R-alpha;IL-6RA;IL-6R 1;Membrane glycoprotein 80;gp80;CD126;IL6R;
Tissue Specificity	Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P08887
Gene Id	3570
Gene Name	IL6R
Subcellular Location	Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 66576.<br /><br />2. Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J (Jan 2004). " determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. 279 (1): 5716.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001248-1	A01425-1	100 ug	-	$370		Add to Cart
BHA21001248-2	A01425-1-10ug	10 ug	Sample	$99		Add to Cart
BHA21001248-3	A01425-1-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001248-4	A01425-1-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001248-5	A01425-1-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001248-6	A01425-1-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001248-7	A01425-1-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001248-8	A01425-1-FITC	100 ug	FITC	$570		Add to Cart
BHA21001248-9	A01425-1-HRP	100 ug	HRP	$570		Add to Cart
BHA21001248-10	A01425-1-APC	100 ug	APC	$670		Add to Cart
BHA21001248-11	A01425-1-PE	100 ug	PE	$670		Add to Cart
BHA21001248-12	A01425-1-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001248-13	A01425-1-carrier-free	100 ug	carrier-free	$370		Add to Cart

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