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Home / Primary Antibodies / Polyclonal Antibodies

Anti-IL-22/IL22 Antibody Picoband®

SKU : BHA21001251

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Mfr.No.	A00963-1, A00963-1-10ug, A00963-1-Biotin, A00963-1-Cy3, A00963-1-Dylight488, A00963-1-Dylight550, A00963-1-Dylight594, A00963-1-FITC, A00963-1-HRP, A00963-1-APC, A00963-1-PE, A00963-1-iFluor647, A00963-1-carrier-free
Alternative Names	Interleukin-22
Background	Interleukin-22 (IL-22), also known as ILTIF, is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. Using FISH, the IL22 gene is mapped to chromosome 12q15, close to the IFNG and the herpesvirus saimiri-induced AK155 genes. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. It also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-IL-22/IL22 Antibody Picoband® catalog # A00963-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that contributes to the inflammatory response in vivo.
Host	Rabbit
Immunogen Region	E. coli-derived human IL-22 recombinant protein (Position: A34-I179). Human IL-22 shares 81.4% amino acid (aa) sequence identity with mouse IL-22.
Isotype	Rabbit IgG
Molecular Weight	24 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Interleukin-22;IL-22;Cytokine Zcyto18;IL-10-related T-cell-derived-inducible factor;IL-TIF;IL22;ILTIF, ZCYTO18;UNQ3099/PRO10096;
Tissue Specificity	Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090). Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501). Expressed in breast cancers (at protein level) (PubMed:26565916). Expressed in hematopoietic cells (PubMed:8499623).
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q9GZX6
Gene Id	50616
Gene Name	IL22
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse<br> ELISA(Cap) , 1-5ug/ml, Human,

Reference	1. Dumoutier, L., Van Roost, E., Ameye, G., Michaux, L., Renauld, J.-C. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immunity 1: 488-494, 2000.<br /><br />2. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001). "Interleukin-10 and the interleukin-10 receptor". Annu. Rev. Immunol. 19: 683765.<br /><br />

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001251-1	A00963-1	100 ug	-	$370		Add to Cart
BHA21001251-2	A00963-1-10ug	10 ug	Sample	$99		Add to Cart
BHA21001251-3	A00963-1-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001251-4	A00963-1-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001251-5	A00963-1-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001251-6	A00963-1-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001251-7	A00963-1-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001251-8	A00963-1-FITC	100 ug	FITC	$570		Add to Cart
BHA21001251-9	A00963-1-HRP	100 ug	HRP	$570		Add to Cart
BHA21001251-10	A00963-1-APC	100 ug	APC	$670		Add to Cart
BHA21001251-11	A00963-1-PE	100 ug	PE	$670		Add to Cart
BHA21001251-12	A00963-1-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001251-13	A00963-1-carrier-free	100 ug	carrier-free	$370		Add to Cart

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