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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Human respiratory syncytial virus(RSV)(B1) Glycoprotein G/RSV-G Protein Polyclonal Antibody

SKU : BHA10324332

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	E-AB-V1273
Background	Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. It is classified within the genus pneumovirus of the family paramyxoviridae. Like other members of the family, HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. HRSV G protein is a type II glycoprotein of 289-299 amino acids (depending on the virus strain) with a signal/anchor hydrophobic domain and is extensively modified by the addition of both N-and O-linked oligosaccharides to achieve the mature form of 8-9 kDa. The C-terminal ectodomain of the G protein has a central region and four cysteines which are conserved in all HRSV isolates and have been proposed as the putative receptor binding site. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. As similar to mucins in amino acid compositions, the RSV G protein can interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, and thus modulates the immune response and facilitate infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors. Unlike the other paramyxovirus attachment proteins, HRSV-G lacks both neuraminidase and hemagglutinating activities.
Host	Rabbit
Immunogen	Recombinant Human RSV (B1) glycoprotein G / RSV-G Protein (His Tag)
Isotype	IgG
Reactivity	RSV

Buffer	0.2 um filtered solution in PBS
Concentration	1mg/mL
Purification	Antigen Affinity
Storage	Store at -20?. Avoid freeze / thaw cycles.

Applications	WB, ELISA
Dilution	WB 1:1000-1:5000 ELISA 1:5000-1:10000

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10324332	E-AB-V1273	50?L	$250		Add to Cart
BHA10324332	E-AB-V1273	100?L	$415		Add to Cart

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