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Home / Primary Antibodies / Polyclonal Antibodies

Anti-HDAC8 Antibody Picoband®

SKU : BHA21003863

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Mfr.No.	A01843-1, A01843-1-10ug, A01843-1-Biotin, A01843-1-Cy3, A01843-1-Dylight488, A01843-1-Dylight550, A01843-1-Dylight594, A01843-1-FITC, A01843-1-HRP, A01843-1-APC, A01843-1-PE, A01843-1-iFluor647, A01843-1-carrier-free
Alternative Names	bone morphogenetic protein 15
Background	HDAC8, Histone deacetylase 8, is an enzyme that in humans is encoded by the HDAC8 gene, and is biologically involved in skull morphogenesis and metabolic control of the ERR-alpha/PGC1-alpha transcriptional complex. Sequence analysis predicted that the 377-amino acid HDAC8 protein contains the 9 conserved HDAC blocks that are presumably important for catalytic function. HDAC8 shares 54% sequence similarity with HDAC1 and HDAC2 and 39% similarity with HDAC3, making it a class I HDAC. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-HDAC8 Antibody Picoband® catalog # A01843-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa). Ovarian phy
Host	Rabbit
Immunogen Region	E.coli-derived human HDAC8 recombinant protein (Position: D29-E347).
Isotype	Rabbit IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B; BMP15; GDF9B
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9BY41
Gene Id	55869
Gene Name	HDAC8
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat ELISA, 0.1-0.5 ug/ml, -

Reference	1. Buggy, J. J., Sideris, M. L., Mak, P., Lorimer, D. D., McIntosh, B., Clark, J. M.Cloning and characterization of a novel human histone deacetylase, HDAC8.Biochem. J. 350: 199-205, 2000. 2. Hu, E., Chen, Z., Fredrickson, T., Zhu, Y., Kirkpatrick, R., Zhang, G.-F., Johanson, K., Sung, C.-M., Liu, R., Winkler, J.Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor.J. Biol. Chem. 275: 15254-15264, 2000. 3. Vannini, A., Volpari, C., Filocamo, G., Casavola, E. C., Brunetti, M., Renzoni, D., Chakravarty, P., Paolini, C., De Francesco, R., Gallinari, P., Steinkuhler, C., Di Marco, S.Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.Proc. Nat. Acad. Sci. 101: 15064-15069, 2004.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003863-1	A01843-1	-	100 ug	$370		Add to Cart
BHA21003863-2	A01843-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003863-3	A01843-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003863-4	A01843-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003863-5	A01843-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003863-6	A01843-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003863-7	A01843-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003863-8	A01843-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003863-9	A01843-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003863-10	A01843-1-APC	APC	100 ug	$670		Add to Cart
BHA21003863-11	A01843-1-PE	PE	100 ug	$670		Add to Cart
BHA21003863-12	A01843-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003863-13	A01843-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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