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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ERK2/MAPK1 Antibody Picoband®

SKU : BHA21006707

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Mfr.No.	PA1310, PA1310-10ug, PA1310-Biotin, PA1310-Cy3, PA1310-Dylight488, PA1310-Dylight550, PA1310-Dylight594, PA1310-FITC, PA1310-HRP, PA1310-APC, PA1310-PE, PA1310-iFluor647, PA1310-carrier-free
Alternative Names	Mitogen-activated protein kinase 1
Background	Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an enzyme which in humans is encoded by the MAPK1 gene. The gene is mapped to 22q11.2. And The protein encoded by this gene is a member of the MAP kinase family. The deduced 360-amino acid human ERK2 protein shares 98% identity with rat Erk2. The MAP kinase ERK2 is widely involved in eukaryotic signal transduction. Upon activation, it translocates to the nucleus of the stimulated cell, where it phosphorylates nuclear targets. Futhermore, the ERK pathway is necessary for experience-dependent plasticity and for long-term potentiation of synaptic transmission in the developing visual cortex. And the MAPK pathway is also involved in responses to NTN1.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ERK2/MAPK1 Antibody catalog # PA1310. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initia
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human ERK2, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	24 kDa, 12 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Mitogen-activated protein kinase 1;MAP kinase 1;MAPK 1;2.7.11.24;ERT1;Extracellular signal-regulated kinase 2;ERK-2;MAP kinase isoform p42;p42-MAPK;Mitogen-activated protein kinase 2;MAP kinase 2;MAPK 2;MAPK1;ERK2, PRKM1, PRKM2;
Tissue Specificity	Heart muscle (at protein level). .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P28482
Gene Name	MAPK1
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Subcellular Location	Cytoplasm, cytoskeleton, spindle . Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Owaki H, Makar R, Boulton TG, Cobb MH, Geppert TD (February 1992). "Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs". Biochem. Biophys. Res. Commun. 182 (3): 141622.<br /><br />2. Li, L.; Wysk, M.; Gonzalez, F. A.; Davis, R. J. : Genomic loci of human mitogen-activated protein kinases. Oncogene 9: 647-649, 1994. <br /><br />3. Owaki, H.; Makar, R.; Boulton, T. G.; Cobb, M. H.; Geppert, T. D. : Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. Biochem. Biophys. Res. Commun. 182: 1416-1422, 1992. <br /><br />4. Khokhlatchev, A. V.; Canagarajah, B.; Wilsbacher, J.; Robinson, M.; Atkinson, M.; Goldsmith, E.; Cobb, M. H. : Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell 93: 605-615, 1998. <br /><br />5. Di Cristo, G.; Berardi, N.; Cancedda, L.; Pizzorusso, T.; Putignano, E.; Ratto, G. M.; Maffei, L. : Requirement of ERK activation for visual cortical plasticity. Science 292: 2337-2340, 2001. <br /><br />6. Forcet, C.; Stein, E.; Pays, L.; Corset, V.; Llambi, F.; Tessier-Lavigne, M.; Mehlen, P. : Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417: 443-447, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006707-1	PA1310	-	100 ug	$370		Add to Cart
BHA21006707-2	PA1310-10ug	Sample	10 ug	$99		Add to Cart
BHA21006707-3	PA1310-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006707-4	PA1310-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006707-5	PA1310-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006707-6	PA1310-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006707-7	PA1310-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006707-8	PA1310-FITC	FITC	100 ug	$570		Add to Cart
BHA21006707-9	PA1310-HRP	HRP	100 ug	$570		Add to Cart
BHA21006707-10	PA1310-APC	APC	100 ug	$670		Add to Cart
BHA21006707-11	PA1310-PE	PE	100 ug	$670		Add to Cart
BHA21006707-12	PA1310-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006707-13	PA1310-carrier-free	carrier-free	100 ug	$370		Add to Cart

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