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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Epac1/RAPGEF3 Antibody Picoband®

SKU : BHA21003444

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Mfr.No.	A02483-3, A02483-3-10ug, A02483-3-Biotin, A02483-3-Cy3, A02483-3-Dylight488, A02483-3-Dylight550, A02483-3-Dylight594, A02483-3-FITC, A02483-3-HRP, A02483-3-APC, A02483-3-PE, A02483-3-iFluor647, A02483-3-carrier-free
Alternative Names	fatty acid binding protein 1
Background	Rap guanine nucleotide exchange factor 3 also known as exchange factor ly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene. As the name suggests, EPAC proteins (EPAC1 and EPAC2) are a family of intracellular sensors for cAMP, and function as nucleotide exchange factors for the Rap subfamily of RAS-like small GTPases.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Epac1/RAPGEF3 Antibody Picoband® catalog # A02483-3. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (By similarity). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involv
Host	Rabbit
Immunogen Region	E.coli-derived human Epac1/RAPGEF3 recombinant protein (Position: H49-R881).
Isotype	Rabbit IgG
Molecular Weight	104 kDa
Reactivity	Human, Mouse, Monkey
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Fatty acid-binding protein, liver; Fatty acid-binding protein 1; Liver-type fatty acid-binding protein; L-FABP; Squalene- and sterol-carrier protein; SCP; Z-protein; p14; Fabp1
Tissue Specificity	Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma. Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O95398
Gene Id	10411
Gene Name	RAPGEF3
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Monkey<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. de Rooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A., Bos, J. L. Epac is a Rap1 guanine-nucleotide-exchange factor ly activated by cyclic AMP. Nature 396: 474-477, 1998. <br /><br />2. Dodge-Kafka, K. L., Soughayer, J., Pare, G. C., Michel, J. J. C., Langeberg, L. K., Kapiloff, M. S., Scott, J. D. The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature 437: 574-578, 2005.<br /><br />3. Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E., Graybiel, A. M. A family of cAMP-binding proteins that ly activate Rap1. Science 282: 2275-2279, 1998.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003444-1	A02483-3	-	100 ug	$370		Add to Cart
BHA21003444-2	A02483-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003444-3	A02483-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003444-4	A02483-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003444-5	A02483-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003444-6	A02483-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003444-7	A02483-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003444-8	A02483-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003444-9	A02483-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003444-10	A02483-3-APC	APC	100 ug	$670		Add to Cart
BHA21003444-11	A02483-3-PE	PE	100 ug	$670		Add to Cart
BHA21003444-12	A02483-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003444-13	A02483-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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