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Home / Primary Antibodies / Polyclonal Antibodies

Anti-BAG1 Antibody Picoband®

SKU : BHA21002808

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Mfr.No.	A02423-3, A02423-3-10ug, A02423-3-Biotin, A02423-3-Cy3, A02423-3-Dylight488, A02423-3-Dylight550, A02423-3-Dylight594, A02423-3-FITC, A02423-3-HRP, A02423-3-APC, A02423-3-PE, A02423-3-iFluor647, A02423-3-carrier-free
Alternative Names	BAG family molecular chaperone regulator 1
Background	BAG family molecular chaperone regulator 1 (BAG1) is a protein that in humans is encoded by the BAG1 gene. Human BAG1 is mapped to chromosome 9p12, a region associated with hereditary disorders that may involve developmental dysregulation of programmed cell death. The Bag1 protein is rich in glutamic acid residues. Its deduced 274-amino acid protein has a calculated molecular mass of 31 KD. Being the BCL-2-associated athanogene, Bag1 enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-BAG1 Antibody Picoband® catalog # A02423-3. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human BAG1, which shares 91.4% and 88.6% amino acid (aa) sequence identity with mouse and rat BAG1, respectively.
Isotype	Rabbit IgG
Molecular Weight	33 kDa(S), 46 kDa(M), 56 kDa(L)
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	BAG family molecular chaperone regulator 1;BAG-1;Bcl-2-associated athanogene 1;BAG1;HAP;
Tissue Specificity	Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). .
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q99933
Gene Id	573
Gene Name	BAG1
Subcellular Location	Isoform 1: Nucleus. Cytoplasm. Isoform 1 localizes predominantly to the nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br>

Reference	1. Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (Mar 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 27984. <br /><br />2. Takayama, S., Kochel, K., Irie, S., Inazawa, J., Abe, T., Sato, T., Druck, T., Huebner, K., Reed, J. C.Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.Genomics35: 494-498, 1996.<br /><br />3. "Entrez Gene: BAG1 BCL2-associated athanogene".<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002808-1	A02423-3	-	100 ug	$370		Add to Cart
BHA21002808-2	A02423-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21002808-3	A02423-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002808-4	A02423-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002808-5	A02423-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002808-6	A02423-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002808-7	A02423-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002808-8	A02423-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21002808-9	A02423-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21002808-10	A02423-3-APC	APC	100 ug	$670		Add to Cart
BHA21002808-11	A02423-3-PE	PE	100 ug	$670		Add to Cart
BHA21002808-12	A02423-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002808-13	A02423-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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