Rabbit Anti-Yeast AHA1p Polyclonal

Mfr.No.	SPC-204, SPC-204D, SPC-204D-A390, SPC-204D-A488, SPC-204D-A594, SPC-204D-ALP, SPC-204D-APC, SPC-204D-BI, SPC-204D-FITC, SPC-204D-HRP, SPC-204D-PCP, SPC-204D-RPE
Immunogen Species	Yeast
Alternative Names	Activator of 90 kDa heat shock protein ATPase homolog 1 Antibody, Aha1 Antibody, SHSA1 Antibody, HSPC322 Antibody, p38 Antibody
Categories	Antibodies
Cellular Localization	Endoplasmic Reticulum, Cytoplasm
Certificate Of Analysis	0.5 ug/ml of SPC-204 was sufficient for detection of Aha1p in 20 ug of W303 yeast lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Yeast AHA1p Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Yeast Aha1 raised against peptide (CESQVKSNYTRGNQK)-KLH fusion, Saccharomyces Cerivisiae (Yeast)
Immunogen Region	Yeast Aha1 raised against peptide (CESQVKSNYTRGNQK)-KLH fusion
Launch Date	2013/04/02
Net Weight (g)	0.1
Reactivity	Yeast
Recombinant	FALSE
Regulatory	RUO
Species	Saccharomyces Cerivisiae (Yeast)
Species Reactivity Medium	Yeast

Swissprot	Q12449
Accession Number	NP_010500.3
Gene Id	851800
Target	AHA1p
Research Area	Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Protein Trafficking

Buffer	Rabbit Antiserum, PBS, 50% glycerol
Dilutions	WB (1:2500); optimal dilutions for assays should be determined by the user.
Purification	Rabbit Antiserum
Scientific Background	Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~ 38kDa. Can run up to 45kDa on SDS Page.
Storage	-20ºC
Storage Buffer	Rabbit Antiserum, PBS, 50% glycerol, *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB
Description	WB
Dilution	WB (1:2500); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub. 2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796. 3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723. 4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11907413-1	SPC-204D	Unconjugated	100 ul	$306	Add to Cart
BHA11907413-2	SPC-204D-A390	ATTO 390	100 ul	$360	Add to Cart
BHA11907413-3	SPC-204D-A488	ATTO 488	100 ul	$359	Add to Cart
BHA11907413-4	SPC-204D-A594	ATTO 594	100 ul	$359	Add to Cart
BHA11907413-5	SPC-204D-ALP	Alkaline Phosphatase	100 ul	$352	Add to Cart
BHA11907413-6	SPC-204D-APC	APC	100 ul	$358	Add to Cart
BHA11907413-7	SPC-204D-BI	Biotin	100 ul	$354	Add to Cart
BHA11907413-8	SPC-204D-FITC	FITC	100 ul	$350	Add to Cart
BHA11907413-9	SPC-204D-HRP	HRP	100 ul	$345	Add to Cart
BHA11907413-10	SPC-204D-PCP	PerCP	100 ul	$358	Add to Cart
BHA11907413-11	SPC-204D-RPE	RPE	100 ul	$355	Add to Cart

AHA1p Antibody - SPC-204