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Home / Primary Antibodies / Polyclonal Antibodies

ACD antibody

SKU : BHA10800077

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Mfr.No.	FNab00078
Alternative Names	ACD ; PIP1 ; PTOP ; TINT1 ; TPP1
Background	Component of the shelterin complex(telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Categories	Primary Antibodies
Cellular Localization	Chromosome, Nucleus, Telomere
Clonality	polyclonal
Description	Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Host	Rabbit
Immunogen	adrenocortical dysplasia homolog(Mouse)
Isotype	IgG
Molecular Weight	58 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Chromosome, Nucleus, Telomere
Synonyms	ACD, PIP1, PTOP, TINT1, TPP1

Antigen	ACD
Uniprot	Q96AP0
Gene Id	65057
Weight	58kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500-1:5000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10800077	FNab00078	100ug	$240		Add to Cart

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